| Gene Symbol | ATG5 |
| Full Name | ATG5 Protein |
| Chromosome | 6q21 |
| Function | ATG5 is central to autophagy: - Autophagosome formation: Essential for the expansion and closure of the autophagosome - ATG12-ATG5-ATG16L1 complex: Functions as an E3-like enzyme for LC3 lipidation - |
| Subcellular Localization | </strong></td><td>Cytoplasm, Autophagosome</td></tr> |
| Molecular Weight | ~32 kDa |
| Pathways | AUTOPHAGY_PATHWAY, Autophagy, Camp Signaling, Chaperone, Chemoresistance |
| GeneCards | ATG5 |
| Human Protein Atlas | ATG5 |
| ATG5 modulators | Compounds that enhance ATG5 function to boost autophagic flux |
| Gene therapy | AAV-mediated ATG5 expression to restore autophagy in aging neurons |
| Autophagy enhancers | Rapamycin and other mTOR inhibitors indirectly enhance ATG5-dependent autophagy |
| Combination approaches | ATG5 activation with aggregate-clearing agents |
| Associated Diseases | AD, Als, AMI, ARM, Ataxia |
| Known Drugs/Compounds | curcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN, statins |
| Interactions | 4E-BP1, ABCA1, ABCG1, ACETYL-COA, ACHE, ACSL4 |
| KG Connections | 1773 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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