concept

PLAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

11Hypotheses

0Analyses

23Outgoing

15Incoming

2Experiments

0Debates

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💡 Concept Info

Name	PLAT
Key Genes/Proteins	ABCA1, ALZHEIMER, ALZHEIMER'S DISEASE, App, APP, CASP4
Related Diseases	Als, ALS, Alzheimer, Brain Hemorrhagic Transformation, Hemorrhagic Transformation

Pathway Diagram

graph TD
    PLAT["PLAT"]
    PLAT -->|"causes"| Hemorrhagic_Transformation["Hemorrhagic Transformation"]
    PLAT -->|"causes"| Brain_Hemorrhagic_Transformati["Brain Hemorrhagic Transformation"]
    PLAT -->|"regulates"| Alzheimer["Alzheimer"]
    PLAT -->|"regulates"| Als["Als"]
    PLAT -->|"regulates"| ALS["ALS"]
    PLAT -->|"contributes to"| Inflammation["Inflammation"]
    PLAT -->|"interacts"| GENES["GENES"]
    PLAT -->|"regulates"| ALZHEIMER["ALZHEIMER"]
    PKD2["PKD2"] -->|"interacts"| PLAT
    PSMB5["PSMB5"] -->|"contributes to"| PLAT
    NEP["NEP"] -->|"contributes to"| PLAT
    PARK7["PARK7"] -->|"contributes to"| PLAT
    GENES -->|"contributes to"| PLAT
    INFLAMMATION["INFLAMMATION"] -->|"contributes to"| PLAT
    CASP4["CASP4"] -->|"contributes to"| PLAT
    ALZHEIMER -->|"regulates"| PLAT

Outgoing (23)

Target	Relation	Type	Str
Ischemic Stroke	treats	disease	0.95
Hemorrhagic Transformation	causes	phenotype	0.95
Brain Hemorrhagic Transformation	causes	disease	0.80
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	contributes_to	disease	0.65
GENES	interacts_with	gene	0.60
PARK7	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
ABCA1	contributes_to	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
Neurogenesis	contributes_to	pathway	0.60
Oxidative Stress	contributes_to	pathway	0.60
APP	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
CASP4	contributes_to	gene	0.60
PSMB5	contributes_to	gene	0.60
NEP	contributes_to	gene	0.60
App	interacts_with	protein	0.60
PKD2	interacts_with	gene	0.60
Ca1	expressed_in	brain_region	0.55

Incoming (15)

Source	Relation	Type	Str
GENES	contributes_to	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
CASP4	contributes_to	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	contributes_to	gene	0.60
GNB5	contributes_to	gene	0.60
SNCA	contributes_to	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ABCA1	contributes_to	gene	0.60
PKD2	interacts_with	gene	0.60
PSMB5	contributes_to	gene	0.60
NEP	contributes_to	gene	0.60
PARK7	contributes_to	gene	0.60

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VPS35 retromer activation prevents endosomal tau templating	0.740	neurodegeneration	Which tau propagation mechanism predomin
A tau PTM barcode gates trans-synaptic templating	0.738	neurodegeneration	Seed-competent tau conformers in trans-s
Mitochondrial SPM Synthesis Platform Engineering	0.647	neurodegeneration	Neuroinflammation resolution mechanisms
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracell	0.630	neurodegeneration	Investigate prion-like spreading of tau
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon	0.629	neurodegeneration	CRISPR-based therapeutic approaches for

H7: Aberrant RNA Template Switching Converts Granules to Agg	0.625	neurodegeneration	How do pathological stress granules tran
Glycosaminoglycan Template Disruption Approach	0.597	neurodegeneration	Protein aggregation cross-seeding across
Pharmacogenomic CNS Drug Optimization Platform	0.524	neurodegeneration	How do neurodegeneration gene expression
Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Ta	0.520	neurodegeneration	Investigate prion-like spreading of tau
Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulatio	0.480	neurodegeneration	What determines P2RY12 receptor expressi
Amyloidogenic segments undergo conformational templating by	0.380	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
E2F coordination of G2/M transcriptional program	exploratory		0.750	0.00	endocycling mammalian cells	proposed	N/A
s:** - ALOX15 overexpression in healthy astrocytes should be protectiv	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826]	He G, Zhang Y, Feng Y, Chen T, Liu M, Ze	J Cell Mol Med	2024	1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434]	Li C, Zhang Y, Liu J, Kang R, Klionsky D	Autophagy	2021	1
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential th [PMID:32222525]	Chen F, Ghosh A, Lin J, Zhang C, Pan Y,	Brain Behav Immun	2020	1
Decoding cell death signals in liver inflammation. [PMID:23567086]	Brenner C, Galluzzi L, Kepp O, Kroemer G	J Hepatol	2013	1
Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437]	Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L	Biomedical materials (Bristol,	2026	0
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405]	Li S, Yan Z, Zhi X, Zheng W, Zhang Z et	Bioact Mater	2026	0
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939]	Wan D, Qi Y, Kang Y, Liang F, Wang Q et	RSC Med Chem	2026	0
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560]	Lee S, Park S, Bang H, Kim SU, Park YH e	Genes (Basel)	2026	0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026	0
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708]	Buneeva OA, Medvedev AE	Biomed Khim	2026	0
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978]	Deng IB, Bu M, Follett J, Sharp R, Mamai	bioRxiv	2026	0
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440]	Santinelli L, Pratuseviciute N, Lange LM	Mov Disord	2026	0
Genome editing in Parkinson's disease: Unlocking therapeutic avenues through CRI [PMID:41905621]	["Singh R", "Maity P", "Jaiswal C"]	Neurochemistry international	2026	0
Targeting Non-coding RNAs in Neurodegeneration: Advances in Therapeutic RNA Moda [PMID:41588889]	["Thakur A", "Chowdhury K", "Kumar A", "	Current Alzheimer research	2026	0
Hereditary Polyneuropathies in the Era of Precision Medicine: Genetic Complexity [PMID:41595476]	["Chrysostomaki M", "Chatzi D", "Kyriako	Genes	2026	0
Neuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic [PMID:41918200]	["Khanal P", "Balmik A"]	CNS & neurological disorders d	2026	0
Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to i [PMID:40773543]	Bachtel ND, Cullen JL, Liu M, Erickson S	Science (New York, N.Y.)	2025	0
CRISPR-Cas technologies in neurodegenerative disorders: mechanistic insights, th [PMID:41674784]	["Yashooa R", "Nabi A", "Smail S", "Azee	Frontiers in neurology	2025	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLAT in their description or question text

H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone

Score: 0.625 · neurodegeneration · 2026-04-22

## Mechanistic Overview H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone starts from the claim

Glycosaminoglycan Template Disruption Approach

Score: 0.597 · neurodegeneration · 2026-04-02

Heparan sulfate and other glycosaminoglycans serve as nucleation templates that facilitate cross-seeding by concentratin

Pharmacogenomic CNS Drug Optimization Platform

Score: 0.524 · neurodegeneration · 2026-04-12

## **Molecular Mechanism and Rationale** The pharmacogenomic CNS drug optimization platform leverages fundamental diffe

Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Tau Clearance and Limi

Score: 0.520 · neurodegeneration · 2026-04-22

## Mechanistic Overview Restoring AQP4 Astrocyte Polarization Enhances Glymphatic Tau Clearance and Limits Template-Depe

Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation

Score: 0.480 · neurodegeneration · 2026-04-21

## Mechanistic Overview Platelet-Derived PDGF-BB Primes VSMCs for P2RY12 Upregulation starts from the claim that modulat

Amyloidogenic segments undergo conformational templating by HSP90-HSP70 heteroco

Score: 0.380 · protein biochemistry · 2026-04-27

The recognition and remodeling of amyloidogenic protein species involves a sequential conformational templating mechanis