gene 1,827 words KG: NESTIN
Contents

NESTIN: Intermediate Filament Protein in Neural Stem Cells and Neurodegeneration

🧬 Gene Info
Gene SymbolNESTIN
Chromosome1q23.1
Protein FamilyClass VI intermediate filaments
Functionis a protein encoded by the NES gene.
Primary Expressionneural stem and progenitor cells during development and in adult neurogenic regions[@reynolds1992]:
Subcellular LocalizationCytoplasm, intermediate filaments
Molecular Weight220 kDa
Amino Acids4477 aa
PathwaysCircadian Rhythm, Mapk, Mitochondrial Function, Wnt
UniProt IDP48681
NCBI Gene ID4756
Ensembl IDENSG00000132688
GeneCardsNESTIN
Human Protein AtlasNESTIN
N-terminal head domainHighly charged, involved in protein-protein interactions
Associated DiseasesNeurodevelopmental disorders, Brain tumors, Alzheimer's disease, Parkinson's disease, Stroke
InteractionsAKT, ALDH1L1, ALZHEIMER, ALZHEIMER'S DISEASE, AND, ARC
KG Connections168 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Knowledge Graph (12 edges)

SOX2 expressed_in NESTIN
EGF expressed_in NESTIN
GFAP expressed_in NESTIN
NESTIN expressed_in ALDH1L1
NESTIN expressed_in NOTCH1
NESTIN expressed_in DLK2
DLK2 expressed_in NESTIN
ALDH1L1 expressed_in NESTIN
NESTIN expressed_in GFAP
NGF activates NESTIN

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