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mechanism 2,324 words KG: GBA
Contents

gaucher-disease-pathway

⚙ Mechanism Info
NameGBA
Key Genes/ProteinsAADC, ABCA7, ABCD3, ACHE, ACTB, Actin
Related DiseasesAging
Related PathwaysAkt
Linked Hypotheses1 hypotheses

No AI portrait yet

Knowledge Graph

Related Hypotheses (16)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38Transcriptional Autophagy-Lysosome Coupling
Score: 0.88Noradrenergic-Tau Propagation Blockade
Score: 0.71Autophagosome Maturation Checkpoint Control
Score: 0.71Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65VCP-Mediated Autophagy Enhancement
Score: 0.59Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Mitochondrial RNA Granule Rescue Pathway
Score: 0.66FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (30)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

CAT interacts_with GBA
OPTN interacts_with GBA
DNM1L interacts_with GBA
CANX interacts_with GBA
LGALS3 interacts_with GBA
CALCOCO2 interacts_with GBA
PEX3 interacts_with GBA
SQSTM1 interacts_with GBA
BCL2 interacts_with GBA
LMNA interacts_with GBA

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