Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GZMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | GZMA |
| Key Genes/Proteins | AND, APOE, CASP3, CASP4, CASP9, CCR6 |
| Related Pathways | Ferroptosis, FERROPTOSIS |
graph TD
GZMA["GZMA"]
GZMA -->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
GZMA -->|"regulates"| INTESTINAL_BARRIER["INTESTINAL_BARRIER"]
GZMA -->|"regulates"| GPX4["GPX4"]
GZMA -->|"treats"| IBD["IBD"]
GZMA -->|"activates"| EPITHELIAL_CELLS["EPITHELIAL_CELLS"]
GZMA -->|"inhibits"| CD8["CD8"]
GZMA -->|"inhibits"| Ferroptosis["Ferroptosis"]
CD8 -->|"inhibits"| GZMA
GPX4 -->|"inhibits"| GZMA
CD4["CD4"] -->|"activates"| GZMA
LDLR["LDLR"] -->|"activates"| GZMA
FOXP3["FOXP3"] -->|"activates"| GZMA
APOE["APOE"] -->|"activates"| GZMA
FERROPTOSIS -->|"inhibits"| GZMA| Target | Relation | Type | Str |
|---|---|---|---|
| GPX4-mediated ferroptosis | suppressed | process | 0.80 |
| FERROPTOSIS | inhibits | pathway | 0.72 |
| INTESTINAL_BARRIER | regulates | phenotype | 0.72 |
| Immune Response | involved_in | process | 0.70 |
| GPX4 | regulates | gene | 0.64 |
| EPITHELIAL_CELLS | activates | cell_type | 0.64 |
| IBD | treats | disease | 0.64 |
| Ras | regulates | protein | 0.60 |
| Ferroptosis | inhibits | pathway | 0.60 |
| CD163 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| FOXP3 | activates | gene | 0.60 |
| LDLR | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| CCR6 | activates | gene | 0.60 |
| GPX4 | inhibits | gene | 0.60 |
| CD8 | inhibits | gene | 0.60 |
| Epithelial | inhibits | cell_type | 0.60 |
| PYROPTOSIS | associated_with | gene | 0.60 |
| IL6 | biomarker_for | gene | 0.60 |
| CASP4 | biomarker_for | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Epithelial Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GZMA in their description or question text
No additional research found