gene 1,027 words KG: TF
Contents

TF

🧬 Gene Info
Gene SymbolTF
Full NameTransferrin
Chromosome3q22.1
Functionis a single-chain glycoprotein folded into two homologous lobes (N-lobe and C-lobe), each containing a single iron-binding site.
Molecular Weight80 kDa
PathwaysIron uptake
UniProt IDP02787
NCBI Gene ID7018
OMIM190000
GeneCardsTF
Human Protein AtlasTF
TfR1 dysregulationTfR1 expression is altered in AD neurons, potentially increasing iron uptake into vulnerable cells.[@zecca2004]
Associated Diseasesneurodegeneration
InteractionsMYC, OCT4, TP53, WNT
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING
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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Ferroptosis Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Levodopa-Induced Dyskinesias Mechanism — Experiment Design
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (3)

Neurodegeneration
disease · KG edge: implicated_in
Iron Dyshomeostasis in MSA Pathogenesis Experiment
experiment · KG edge: binds
TFRC
gene · KG edge: binds

Knowledge Graph (12 edges)

Chronic Cerebral Hypoperfusion upregulates TF
TF binds Iron
TF involved_in Iron uptake
MYC inhibits TF
TF inhibits TP53
AXIN1 regulates TF
MYO1C regulates TF
RHEB regulates TF
SOCS3 regulates TF
TF regulates TXNIP

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