gene 534 words KG: RANBP2
Contents

RANBP2 — RAN Binding Protein 2

🧬 Gene Info
Gene SymbolRANBP2
Full NameRAN Binding Protein 2
Chromosome2q12.3
FunctionRANBP2 encodes a massive 3224 amino acid protein that serves as a critical component of the nuclear pore complex (NPC).
Primary Expressionbrainstem nuclei
Molecular Weight358 kDa
Amino Acids3224 aa
PathwaysAutophagy, Glycolysis, RANGAP1-SUMO1 Complex Formation
UniProt IDP49792
NCBI Gene ID9918
Ensembl IDENSG00000136404
OMIM601181
GeneCardsRANBP2
Human Protein AtlasRANBP2
Nucleocytoplasmic transportFacilitating the bidirectional transport of proteins and RNA between nucleus and cytoplasm
Associated DiseasesAcute Necrotizing Encephalopathy
InteractionsAND, AUTOPHAGY, CKAP4, FOXO1, HIF, HIF-1Α
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
CKAP4 — Cytoskeleton-Associated Protein 4
gene · KG edge: activates
FOXO1 Gene
gene · KG edge: interacts_with
NBR1 Gene
gene · KG edge: activates
SUMO1 — Small Ubiquitin-Like Modifier 1
gene · KG edge: activates

Knowledge Graph (12 edges)

SUMO1 interacts_with RANBP2
SUMO2 interacts_with RANBP2
RANBP2 interacts_with SUMO1
RANBP2 interacts_with SUMO2
CKAP4 activates RANBP2
RANBP2 activates NBR1
RANBP2 interacts_with FOXO1
RANBP2 interacts_with UBIQUITIN
RANBP2 activates CKAP4
RANBP2 protects_against SUMO1

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