gene 953 words KG: STAT2
Contents

STAT2 Gene - Signal Transducer and Activator of Transcription 2

🧬 Gene Info
Gene SymbolSTAT2
Full NameSignal Transducer and Activator of Transcription 2
AliasesPage for STAT2 Gene
Chromosome12q13.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight113 kDa
Amino Acids130 aa
PathwaysJAK-STAT signaling
UniProt IDP52630
NCBI Gene ID6773
Ensembl IDENSG00000170581
GeneCardsSTAT2
Human Protein AtlasSTAT2
CompositionSTAT1-STAT2-IRF9 (p48/IFF9) [7]
DNA bindingRecognizes ISRE sequences (TTTCNNTTC) [8]
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, AUTOPHAGY, C1Q, E protein, GENES, IFN
KG Connections75 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Vagal Afferent Microbial Signal Modulation
Score: 0.62

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

IFNAR2 — Interferon Alpha Receptor 2
gene · KG edge: expressed_in
JAK2 Gene - Janus Kinase 2
gene · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: regulates
C1QA Gene — Complement Component 1q A Chain
gene · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates

Knowledge Graph (12 edges)

E protein inhibits STAT2
OPTN inhibits STAT2
NBR1 inhibits STAT2
selective autophagy inhibits STAT2
SADS-CoV E protein inhibits STAT2
STAT2 regulates NBR1
STAT2 regulates OPTN
NBR1 regulates STAT2
OPTN regulates STAT2
JAK1 associated_with STAT2

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