gene 830 words KG: SHANK3
Contents

SHANK3 - SH3 and Multiple Ankyrin Repeat Domains 3

🧬 Gene Info
Gene SymbolSHANK3
Full NameSH3 and Multiple Ankyrin Repeat Domains 3
AliasesPage for SHANK3, Page for SHANK3 Protein
Chromosome22q13.33.
FunctionPostsynaptic density assembly: Recruits and organizes synaptic proteins
Molecular Weight180 kDa
Amino Acids620 aa
UniProt ID[Q9BYB0](https://www.uniprot.org/uniprot/Q9BYB0)
Ensembl IDENSG00000132924
GeneCardsSHANK3
Human Protein AtlasSHANK3
Axon initial segmentAlso present in some neuronal subtypes
Synaptic vesiclesMinor presence
Associated DiseasesAls
InteractionsACC, AND, ANK3, CACNA1G, GENES, KCNH7
KG Connections49 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (3)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in
SHANK2 Gene
gene · KG edge: regulates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: inhibits
CACNA1G Gene
gene · KG edge: inhibits
KMT2D — Lysine Methyltransferase 2D
gene · KG edge: inhibits

Knowledge Graph (12 edges)

MTOR inhibits SHANK3
SHANK3 inhibits SST
SETD1A inhibits SHANK3
GAIN expressed_in SHANK3
KMT2B inhibits SHANK3
SHANK3 inhibits KMT2D
SHANK3 inhibits CACNA1G
SHANK3 inhibits KMT2A
KMT2A inhibits SHANK3
SHANK3 inhibits SETD1A

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