gene 2,575 words KG: SCRIB
Contents

SCRIB Gene

🧬 Gene Info
Gene SymbolSCRIB
Full NameScribble Planar Cell Polarity Protein
AliasesScribble
Chromosome8q24.3
Functionencodes a protein of 1,757 amino acids with a molecular weight of approximately 220 kDa.
Primary ExpressionBrain (cortex, hippocampus, cerebellum), epithelial tissues
Molecular Weight220 kDa
Amino Acids1757 aa
Exons34
PathwaysAutophagy, Inflammasome, Phagocytosis
UniProt IDQ14160
NCBI Gene ID23513
Ensembl IDENSG00000103067
OMIM607584
GeneCardsSCRIB
Human Protein AtlasSCRIB
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsAUTOPHAGY, MICROGLIA, NEURON, NLRP3, PARKINSON, ROS
KG Connections37 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (114)

Multi-Modal Stress Response Harmonization
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Smartphone-Detected Motor Variability Correction
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Phase-Separated Organelle Targeting
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
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Related Analyses (29)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

Microglia
cell · KG edge: activates
Parkinson Basal Ganglia Circuit
circuit · KG edge: activates
NeuRon Therapeutics
company · KG edge: activates
Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: co_discussed

Knowledge Graph (12 edges)

BAK1 co_discussed SCRIB
BAX co_discussed SCRIB
BID co_discussed SCRIB
MTOR co_discussed SCRIB
BDNF co_discussed SCRIB
FGF21 co_discussed SCRIB
HEPSIN co_discussed SCRIB
SCRIB co_discussed STING
APC co_discussed SCRIB
APP co_discussed SCRIB

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