| Gene Symbol | SHARPIN |
| Full Name | SHANK Associated RH Domain Interactor |
| Chromosome | 8q24.3 |
| Function | is a core component of the linear ubiquitin chain assembly complex (LUBAC), the only known E3 ligase capable of generating methionine-1 (M1)-linked polyubiquitin chains. |
| Primary Expression | both neurons and glial cells, though its functional roles differ by cell type: in neurons, SHARPIN primarily functions in postsyn |
| Molecular Weight | 40 kDa |
| Amino Acids | 387 aa |
| Pathways | NF-κB |
| UniProt ID | Q9H0F6 |
| NCBI Gene ID | 81858 |
| Ensembl ID | ENSG00000179526 |
| OMIM | 611885 |
| GeneCards | SHARPIN |
| Human Protein Atlas | SHARPIN |
| TNF receptor 1 (TNFR1) | LUBAC modifies RIPK1 and NEMO with M1-linked ubiquitin chains at the receptor complex, stabilizing pro-survival signaling and preventing RIPK1-dependent cell death |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Ms, neurodegeneration |
| Interactions | NF-ΚB, UBIQUITIN |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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