gene 1,484 words KG: NEFL
Contents

NEFL — Neurofilament Light Chain

🧬 Gene Info
Gene SymbolNEFL
Full NameNeurofilament Light Chain
Chromosome8p21.2
FunctionThese dimers associate in an antiparallel, staggered manner to form tetramers, which then laterally associate into protofilaments and mature 10-nm intermediate filaments.
Primary ExpressionMotor Neurons, Cortical Neurons, Peripheral Nerves, All Neurons (ubiquitous)
Molecular Weight62 kDa
Amino Acids543 aa
Exons4
PathwaysAxonal Transport
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000277586
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAlzheimers_disease
InteractionsALS, AMYOTROPHIC LATERAL SCLEROSIS, BCL2, BNIP3L, C9ORF72, CNR1
KG Connections199 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (3)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · proposed · Score: 0.40

See Also (11)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: interacts_with
AURKB Gene
gene · KG edge: associated_with
BDNF Gene
gene · KG edge: associated_with
CALM1 — Calmodulin 1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NEFL associated_with Alzheimers_disease
IL9 biomarker_for NEFL
VEGFA biomarker_for NEFL
IL4 biomarker_for NEFL
FGF2 biomarker_for NEFL
GFAP biomarker_for NEFL
NPTX1 biomarker_for NEFL
CHIT1 biomarker_for NEFL
MDH1 biomarker_for NEFL
PDGFRB biomarker_for NEFL

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