Contents

PARP1 Gene

🧬 Gene Info

Gene Symbol	PARP1
Aliases	Poly(ADP-ribose) polymerase 1, ADPRT, Poly(ADP-Ribose
Protein Family	PARP family (17 members)
Protein Type	Enzyme
Target Class	Enzyme
Function	Upon DNA binding, PARP1 catalytic activity increases 500-fold, synthesizing PAR chains on itself (automodification) and target proteins[@benjamin1980].
Mechanism of Action	Competitive inhibitors of PARP1 enzymatic activity blocking DNA repair
Druggability	Medium (0.62)
Clinical Stage	Approved
Molecular Weight	113 kDa
Pathways	DNA repair, NAD+ metabolism, Apoptosis, NF-κB
UniProt ID	P09874
GeneCards	PARP1
Human Protein Atlas	PARP1
DNA Damage Detection	Binds to single-strand and double-strand DNA breaks
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	ANTHOCYANINS, EMPAGLIFLOZIN, OLAPARIB, PARPi, PARP inhibitor, Parp Inhibitors
Interactions	A2M, AARS1, ABCG1, ACHE, AD, AGING
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	PARP1 Inhibition Therapy PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Dam Oligodendrocyte DNA Repair Enhancement
KG Connections	1016 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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Knowledge Graph

TGM2 co_discussed PARP1

PRMT1 co_discussed PARP1

PARP1 co_discussed HSPA1A

PARP1 co_discussed G3BP1

PARP1 co_discussed SRPK1

TARDBP co_discussed PARP1

NCSTN interacts_with PARP1

FAS activates PARP1

TNF activates PARP1