| Gene Symbol | GNA11 |
| Full Name | G Protein Subunit Alpha 11 |
| Chromosome | 19q13.42 |
| Function | Gα₁₁ functions as a molecular switch, cycling between an inactive GDP-bound state and an active GTP-bound state upon GPCR activation. |
| Primary Expression | many tissues, with particularly high levels in: - Brain: Cortex, hippocampus, basal ganglia, cerebellum - Endocrine gla |
| Amino Acids | 354 aa |
| Pathways | Akt, Pi3K |
| UniProt ID | [P30678](https://www.uniprot.org/uniprot/P30678) |
| Ensembl ID | ENSG00000127955 |
| GeneCards | GNA11 |
| Human Protein Atlas | GNA11 |
| PLCβ activation | Hydrolysis of PIP₂ to IP₃ and DAG |
| Calcium release | IP₃-mediated calcium release from ER stores |
| PKC activation | DAG-dependent protein kinase C activation |
| Downstream effects | Modulation of ion channels, transcription factors, and cytoskeletal proteins |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, BRAF, ERK, ERK1, GENES, GNAQ |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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