| Gene Symbol | TFR1 |
| Full Name | Transferrin Receptor 1 |
| Chromosome | 3q29 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake |
| Mechanism of Action | Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake |
| Primary Expression | Ubiquitous, highest in proliferating cells and erythroid precursors |
| Druggability | Low (0.44) |
| Clinical Stage | Approved |
| Pathways | Amyloid, Complement, Endocytosis, Oxidative Stress, Phagocytosis |
| UniProt ID | P02786 |
| NCBI Gene ID | 7037 |
| Ensembl ID | ENSG00000149571 |
| GeneCards | TFR1 |
| Human Protein Atlas | TFR1 |
| Associated Diseases | Als, Alzheimer, cancer, Dementia |
| Known Drugs/Compounds | iron-transferrin complex, paricalcitol, valproic acid |
| Interactions | ABCB1, ACSL4, ALOX12, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Magnetosonic-Triggered Transferrin Receptor Cluste |
| KG Connections | 520 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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