| Gene Symbol | DUOX2 |
| Full Name | Dual Oxidase 2 |
| Chromosome | 15q21.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 175 kDa |
| Amino Acids | 548 aa |
| UniProt ID | [Q9NRD9](https://www.uniprot.org/uniprot/Q9NRD9) |
| Ensembl ID | ENSG00000140279 |
| OMIM | 607708 |
| GeneCards | DUOX2 |
| Human Protein Atlas | DUOX2 |
| Peroxidase activity | Unlike other NOX enzymes, DUOX has intrinsic peroxidase activity |
| Calcium dependence | Directly activated by calcium through EF-hand domains |
| Maturation factor requirement | Requires DUOXA2 for proper folding and trafficking |
| [Neurons](/entities/neurons) | Very low expression under normal conditions |
| Associated Diseases | neurodegeneration |
| Interactions | AND, DLL4, DNA, IL1B, IL23A, ROS |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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