gene 690 words KG: CREB1
Contents

CREB1 Gene

🧬 Gene Info
Gene SymbolCREB1
Full NamecAMP Response Element Binding Protein 1
Chromosome2q33.3
Protein TypeTranscription Factor
FunctionCREB1 is a transcription factor that regulates gene expression in response to cAMP and calcium signaling.
Primary Expressionbrain, with high levels in hippocampus, cortex, and striatum
Molecular Weight37 kDa
PathwaysApoptosis, CREB signaling, MAPK signaling, Mapk, Oxidative Phosphorylation
UniProt IDP16220
NCBI Gene ID1385
Ensembl IDENSG00000108748
OMIM123810
GeneCardsCREB1
Human Protein AtlasCREB1
Associated DiseasesBreast Cancer, Cancer, neurodegeneration
InteractionsACTB, Actin, AMPK, APOE, APOPTOSIS, APP
KG Connections242 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (40)

Extracellular Matrix Stiffness Modulation
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Microbial Inflammasome Priming Prevention
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
← Prevpg 2/2

Related Analyses (13)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (15)

OSK Reprogramming and Yamanaka Factors in Neurodegenera
mechanism · Pages share 6 hypotheses
CALB2 Gene
gene · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
BAX Gene
gene · KG edge: activates
BDNF Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TRIM27 interacts_with CREB1
CREB1 activates TFEB
CREB1 regulates PIEZO1
REST activates CREB1
P38 activates CREB1
CREB1 activates PPARGC1A
EP300 interacts_with CREB1
MET expressed_in CREB1
CREBBP activates CREB1
BDNF co_discussed CREB1

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