| Gene Symbol | CLDN5 |
| Full Name | Claudin-5 |
| Chromosome | 22q11.21. |
| Protein Type | Structural Protein |
| Target Class | Structural Protein |
| Function | Tight junction protein modulation - no established druggable mechanisms |
| Mechanism of Action | Tight junction protein modulation - no established druggable mechanisms |
| Primary Expression | Brain endothelial cells, Tight junctions of blood-brain barrier |
| Druggability | Undruggable (0.20) |
| Clinical Stage | Approved |
| Amino Acids | 218 aa |
| Exons | 4 |
| Pathways | Cerebrovascular |
| UniProt ID | O00511 |
| NCBI Gene ID | 9079 |
| Ensembl ID | ENSG00000184113 |
| OMIM | 602507 |
| GeneCards | CLDN5 |
| Human Protein Atlas | CLDN5 |
| Associated Diseases | ALS, blood-retinal barrier integrity, Brain Edema, neurodegeneration, stroke |
| Known Drugs/Compounds | curcumin, resveratrol |
| Interactions | ABCB1, ABCD1, ABCD2, ABCG2, AMYLOID, AND |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Plasma Claudin-5 Proteolytic Fragments Distinguish Vascular-Glial Interface Restoration (+2 more) |
| KG Connections | 392 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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