gene 1,174 words KG: CKAP4
Contents

CKAP4 — Cytoskeleton-Associated Protein 4

🧬 Gene Info
Gene SymbolCKAP4
Full NameCytoskeleton-Associated Protein 4
Chromosome12p13.1
Functionis a type II transmembrane protein localized to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and nuclear envelope.
Primary Expressionthe brain, particularly in motor neurons of the spinal cord and motor cortex
Subcellular Localizationthe endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and nuclear envelope. The protein plays criti
Molecular Weight63 kDa
Amino Acids400 aa
PathwaysWnt signaling
UniProt IDQ07011
NCBI Gene ID10527
Ensembl IDENSG00000129195
OMIM616404
GeneCardsCKAP4
Human Protein AtlasCKAP4
Associated DiseasesAlzheimer's Disease, Cancer
InteractionsADAM15, Akt, AKT, AUTOPHAGY, HIF, HIF-1Α
KG Connections48 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (8)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ABCG1 Gene
gene · KG edge: expressed_in
ADAM15 Gene
gene · KG edge: activates
FAM134B — Family With Sequence Similarity 134 Member B
gene · KG edge: regulates
GAIN Gene - GABA-A Receptor Associated Protein Like 2
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CKAP4 activates RANBP2
CKAP4 activates NBR1
CKAP4 activates AKT
CKAP4 regulates FAM134B
RANBP2 activates CKAP4
NBR1 activates CKAP4
FAM134B regulates CKAP4
AKT activates CKAP4
CKAP4 activates Rb
CKAP4 activates ADAM15

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