| Typical Onset | Average age of onset for sporadic AD (~75-85 years) |
| Inheritance | Co-dominant (one copy from each parent) |
| Gene | APOE (Apolipoprotein E) |
| Chromosome | 19q13.32 |
| SNP ID | rs429358 (Arg130), rs7412 (Arg176) |
| Allele Frequency | ~70-80% in Caucasian populations; ~50-60% globally |
| Nucleotide Changes | C→T at rs429358 (Arg130), C→T at rs7412 (Arg176) |
| N-terminal domain | Receptor-binding region (residues 1-191) |
| C-terminal domain | Lipid-binding region (residues 216-299) |
| Baseline Risk | APOE3 carriers have the **population average AD risk** (approximately 10-15% lifetime risk) |
| Amyloid Deposition | Intermediate burden on PET imaging — less than APOE4, more than APOE2 |
| Cognitive Trajectory | Age-related cognitive decline comparable to non-carriers |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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