gene 1,373 words KG: ent-gene-eb1528a1
Contents

AKT1 Gene

🧬 Gene Info
Gene SymbolAKT1
Full NameAKT Serine/Threonine Kinase 1
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central hub in the PI3K/AKT/mTOR signaling pathway, one of the most critical survival and growth signaling cascades in neurons.
Amino Acids480 aa
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mapk
Ensembl IDENSG00000142208
GeneCardsAKT1
Human Protein AtlasAKT1
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
Known Drugs/CompoundsAndrographis paniculata, Atbc, berberine, Coumestrol, COUMESTROL, DEP
InteractionsACTB, Actin, AGING, AKT, ALZHEIMER, ALZHEIMER DISEASE
KG Connections1550 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (33)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
← Prevpg 2/2

Related Analyses (11)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (6)

ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target
ACTB Gene
gene · KG edge: interacts_with
AKT2 Gene
gene · KG edge: associated_with
AKT3 Gene
gene · KG edge: associated_with
ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3
gene · KG edge: associated_with

Knowledge Graph (2 edges)

ent-gene-eb1528a1 data_in benchmark_ot_ad_answer_key:AKT1
benchmark_ot_ad_answer_key:AKT1 data_in ent-gene-eb1528a1

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