gene 1,547 words KG: ADRA1B
Contents

ADRA1B — Alpha-1B Adrenergic Receptor

🧬 Gene Info
Gene SymbolADRA1B
Full NameAlpha-1B Adrenergic Receptor
Aliasesα1B-AR
Chromosome5q23.3
Protein FamilyAdrenergic receptors (GPCR)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionSmooth muscle, brain, heart
Amino Acids515 aa
UniProt IDP35368
NCBI Gene ID147
Ensembl IDENSG00000170175
GeneCardsADRA1B
Human Protein AtlasADRA1B
Gq protein activationActivates phospholipase Cβ (PLCβ)
PIP2 hydrolysisGenerates IP3 and DAG
Associated Diseasesneurodegeneration
InteractionsADRA1A, AND, DRD1, DRD2, GRIA1, GRIN1
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Orexin-Microglia Modulation Therapy
Score: 0.71
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
DNA Methylation
entity · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
ADRA1A Gene
gene · KG edge: activates
DRD1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

DRD2 activates ADRA1B
HRH3 activates ADRA1B
HCRTR2 activates ADRA1B
ADRA1B activates DRD1
ADRA1B activates GRIA1
ADRA1B activates ADRA1A
ADRA1B activates HRH1
ADRA1B activates GRIN1
ADRA1B activates HCRTR1
ADRA1B activates Rb

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