concept

CSGA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSGA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

1Hypotheses

3Analyses

46Outgoing

25Incoming

0Experiments

3Debates

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💡 Concept Info

Name	CSGA
Key Genes/Proteins	AADC, AGER, alpha-synuclein, Alpha-Synuclein, ALZHEIMER, AMYLOID
Related Diseases	als, Als, alzheimer, Alzheimer, Alzheimer's disease
Related Pathways	biofilm formation

Pathway Diagram

graph TD
    CSGA["CSGA"]
    CSGA -->|"regulates"| Als["Als"]
    CSGA -->|"regulates"| Parkinson["Parkinson"]
    CSGA -->|"interacts"| alpha_synuclein["alpha-synuclein"]
    CSGA -->|"implicated in"| Parkinson_s_disease["Parkinson's disease"]
    CSGA -->|"contributes to"| biofilm_formation["biofilm formation"]
    fibrinogen["fibrinogen"] -->|"inhibits"| CSGA
    AMYLOID["AMYLOID"] -->|"expressed in"| CSGA
    PARKINSON["PARKINSON"] -->|"regulates"| CSGA
    APP["APP"] -->|"activates"| CSGA

Outgoing (46)

Target	Relation	Type	Str
h-90b7b77f59	targeted_by	hypothesis	1.00
SNCA	associated_with	protein	0.90
Parkinson'S Disease	causes	disease	0.85
curli fibril formation	regulates	process	0.70
alpha_synuclein_aggregation	causes	phenotype	0.70
Parkinson	regulates	disease	0.65
Als	regulates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Rb	associated_with	protein	0.60
Rb	interacts_with	protein	0.60
APP	activates	gene	0.60
innate immune system	modulates	cell_type	0.60
contact-phase proteins	interacts_with	protein	0.60
biofilm formation	contributes_to	pathway	0.60
gut microbiome	expressed_in	pathway	0.60
amyloid beta	interacts_with	protein	0.60
neurodegeneration	associated_with	disease	0.60
AMYLOID	expressed_in	gene	0.60
AMYLOID	associated_with	gene	0.60
App	associated_with	protein	0.60
AMYLOID	inhibits	gene	0.60
AMYLOID	regulates	gene	0.60
AMYLOID	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
Fus	expressed_in	protein	0.60
Alzheimer's disease	implicated_in	disease	0.60
alpha-synuclein	interacts_with	protein	0.60
Alpha-Synuclein	regulates	protein	0.60
PARKINSON	regulates	gene	0.60
Parkinson's disease	implicated_in	disease	0.60
DDC	debate_co_mention	gene	0.45
TDC	debate_co_mention	gene	0.45
neuroinflammation	debate_co_mention	process	0.45
GPR109A	debate_co_mention	gene	0.45
HDAC	debate_co_mention	gene	0.45
TLR4	co_associated_with	gene	0.40
GPR109A	co_associated_with	gene	0.40
TDC	co_associated_with	gene	0.40
parkinson	implicated_in	disease	0.35
als	implicated_in	disease	0.35
alzheimer	implicated_in	disease	0.35
ms	implicated_in	disease	0.35

Incoming (25)

Source	Relation	Type	Str
h-90b7b77f59	targets	hypothesis	1.00
h-8b7727c1	targets	hypothesis	0.90
APP	activates	gene	0.60
AMYLOID	expressed_in	gene	0.60
PARKINSON	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	inhibits	gene	0.60
AMYLOID	regulates	gene	0.60
AMYLOID	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
fibrinogen	inhibits	protein	0.60
H3	associated_with	hypothesis	0.50
AADC	debate_co_mention	gene	0.45
AGER	debate_co_mention	gene	0.45
CHRNA7	debate_co_mention	gene	0.45
AGER	co_associated_with	gene	0.40
CHRNA7	co_associated_with	gene	0.40
HDAC	co_discussed	gene	0.40
GPR109A	co_discussed	gene	0.40
TDC	co_discussed	gene	0.40
AGER	co_discussed	gene	0.40
CHRNA7	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40
DDC	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro	0.642	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (3)

Scientific analyses that reference this entity

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

neurodegeneration | 2026-04-12 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.924

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836]	Vinutha AS, Akshay S, Sree Agash SG, Cha	Archives of microbiology	2026
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877]	Gurnani B, Jain N	The Journal of biological chem	2026
Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenera [PMID:40141340]	Singh AA, Khan F, Song M	International journal of molec	2025
E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead [PMID:41476670]	Mygind L, Jensen G, Neesgaard V, Krohn K	Brain, behavior, & immunity -	2025
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenera [PMID:35571084]	Wang C, Zheng C	Frontiers in pharmacology	2022
Genome-wide screen identifies curli amyloid fibril as a bacterial component prom [PMID:34413194]	Wang C, Lau CY, Ma F, Zheng C	Proceedings of the National Ac	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021
Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Pr [PMID:32538869]	Werner T, Horvath I, Wittung-Stafshede P	Journal of Parkinson's disease	2020
7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Gl [PMID:33417205]	["Nury T", "Yammine A", "Menetrier F", "	Advances in experimental medic	2020
Unified single-cell analysis of testis gene regulation and pathology in five mou [PMID:31237565]	Jung M, Wells D, Rusch J, Ahmad S, March	eLife	2019
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parki [PMID:27912057]	["Sampson TR", "Debelius JW", "Thron T",	Cell	2017
Anti-aging effects of coffee. [PMID:28854150]	Keita Takahashi; Akihito Ishigami	Aging	2017
The chronic myeloid leukemia stem cell: stemming the tide of persistence. [PMID:28159740]	Holyoake TL, Vetrie D	Blood	2017
Neurodegeneration in tauopathies and synucleinopathies. [PMID:27344208]	["Foguem C", "Kamsu-Foguem B"]	Revue neurologique	2016
Three months of simvastatin therapy vs. placebo for severe portal hypertension i [PMID:26321186]	Pollo-Flores P, Soldan M, Santos UC, Kun	Digestive and liver disease :	2015

Debates (3)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

closed · Rounds: 4 · Score: 0.84 · 2026-04-12

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CSGA in their description or question text

No additional research found