| Gene Symbol | CCR5 |
| Aliases | CCR5 chemokine receptor |
| Protein Type | Gene |
| Function | CCR5 is a seven-transmembrane G protein-coupled receptor that binds CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES). |
| Molecular Weight | 46 kDa |
| Amino Acids | 352 aa |
| Pathways | MAPK, PI3K |
| UniProt ID | P51681 |
| GeneCards | CCR5 |
| Human Protein Atlas | CCR5 |
| N-terminal extracellular domain | Contains glycosylation sites and contributes to ligand binding specificity |
| Extracellular loops (ECL1-3) | Form the ligand-binding pocket for chemokines |
| Transmembrane domains (TM1-7) | Spanning the cell membrane, connecting to intracellular signaling |
| Intracellular loops (ICL1-3) | Couple to G proteins and β-arrestin |
| C-terminal intracellular tail | Contains serine/threonine residues for phosphorylation and regulation |
| Associated Diseases | Als, Alzheimer, Inflammation, Neuroinflammation, Ptsd |
| Interactions | adcy2, ADCY2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND |
| KG Connections | 278 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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