| Gene Symbol | TDP |
| Full Name | 43 (TAR DNA-Binding Protein 43) — Biomarker |
| Aliases | TDP43 |
| Chromosome | 1p36. |
| Function | TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology. |
| Subcellular Localization | signal ( |
| GeneCards | TDP |
| Human Protein Atlas | TDP |
| N-terminal domain (1-76 aa) | Contains a nuclear localization signal (NLS) and mediates protein-protein interactions. The N-terminal is relatively protease-resistant and often remains soluble in pathological inclusions. |
| Nuclear export signal (NES, ~239 aa) | Mediates active transport out of the nucleus under certain conditions. |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia |
| Interactions | Actin, AKT, ALS, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, ATXN2 |
| KG Connections | 244 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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