gene 1,311 words KG: STMN2
Contents

STMN2 (Stathmin-2)

🧬 Gene Info
Gene SymbolSTMN2
Chromosome8q21.13
FunctionLike other stathmin family members, it can sequester tubulin dimers, reducing the pool of free tubulin available for microtubule polymerization.
Primary ExpressionMotor Neurons, Cortical Neurons, Sensory Neurons, Developing CNS
Molecular Weight20 kDa
PathwaysAxonal Regeneration
Ensembl IDENSG00000104435
GeneCardsSTMN2
Human Protein AtlasSTMN2
Associated DiseasesALS, frontotemporal dementia, neurodegeneration
InteractionsActin, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATP, AXON REGENERATION
SciDEX HypothesesSTMN2 Restoration as a Prerequisite for Axon Growt
KG Connections116 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Arginine Methylation Enhancement Therapy
Score: 0.65
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
PARP1 Inhibition Therapy
Score: 0.74
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

RNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
NeuRon Therapeutics
company · KG edge: interacts_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: interacts_with
CHMP7 mutations cause hereditary spastic paraplegia
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

TDP43 regulates STMN2
POLYADENYLATION inhibits STMN2
STMN2 activates AXONAL_REGENERATION
C9ORF72 interacts_with STMN2
NEFL activates STMN2
CHMP7 expressed_in STMN2
TDP43 binds STMN2
Premature Polyadenylation downregulates STMN2
STMN2 involved_in Axonal Regeneration
STMN2 expressed_in Motor Neurons

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