| Gene Symbol | ADORA2B |
| Chromosome | 17p12 |
| Protein Type | Receptor |
| Function | encodes a G protein-coupled receptor that plays important roles in modulating cellular responses to adenosine. |
| Primary Expression | astrocytes, microglia, neurons, and endothelial cells of the [ |
| Molecular Weight | 44 kDa |
| Pathways | PI3K, MAPK Pathway, NF-κB Pathway, NF-κB |
| UniProt ID | P29274 |
| NCBI Gene ID | 136 |
| Ensembl ID | ENSG00000171490 |
| OMIM | 600446 |
| GeneCards | ADORA2B |
| Human Protein Atlas | ADORA2B |
| Gαs-coupled | Stimulates adenylate cyclase, increasing cAMP levels |
| Low Affinity | Requires higher adenosine concentrations than A2A receptor (Kd ~10-20 μM vs ~0.5-5 μM for A2A) |
| Associated Diseases | Als, Inflammation |
| Known Drugs/Compounds | Caffeine |
| Interactions | F3, FN1, GENES, IL5, INFLAMMATION, OCLN |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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