gene 972 words KG: ACE
Contents

ACE Gene

🧬 Gene Info
Gene SymbolACE
Full NameAngiotensin Converting Enzyme
AliasesACE1, CD143, DCP1
Chromosome17q23.3
Protein TypeProtease
FunctionConverts angiotensin I to angiotensin II
Molecular Weight149.7 kDa
Amino Acids1306
PathwaysRenin-angiotensin system, Bradykinin metabolism
UniProt IDP12821
NCBI Gene ID1636
Ensembl IDENSG00000159640
OMIM106180
GeneCardsACE
Human Protein AtlasACE
Associated DiseasesAls, Alzheimer, Alzheimer's disease, cancer, Cardiac
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND, APOPTOSIS
SciDEX HypothesesMicroglial ACE Enhancement for Amyloid Clearance
KG Connections335 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (11)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Knowledge Graph (12 edges)

ACE activates TNF
ACE therapeutic_target TREM2
ACE therapeutic_target PILRA
ACE therapeutic_target IDUA
ACE therapeutic_target TAU
ACE therapeutic_target GRN
ACE expressed_in NDUFS8
ACE expressed_in LDLR
ACE expressed_in CLU
ACE expressed_in SPG7

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