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Do tau-specific HSP90 conformational states exist that differ from other client protein complexes?

PARTIALLY ADDRESSED

The debate hinged on whether HSP90 adopts unique conformations when bound to tau versus other clients, but no structural evidence was provided. This fundamental question determines whether allosteric tau-selective inhibitors are even theoretically possible. Source: Debate session sess_SDA-2026-04-10-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d (Analysis: SDA-2026-04-09-gap-debate-20260409-201742-5407d57d)

Priority: 0.90 Domain: structural-biology Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: Do tau-specific HSP90 conformational states exist that differ from other client protein complexes? is a 0.9 priority gap in structural-biology. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Do tau-specific HSP90 conformational states exist that differ from other client protein complexes? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
60%
Resolution
0
Mechanistic Families
Gap Resolution Progress60%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (11)

HSP90→NeuroinflammationHSP90→SOD2HSP90→IGF1HSP90→MICROGLIAHSP90→SOD1
▸ Show 6 more

binds (2)

HSP90→SFRP1SFRP1→HSP90

binds to (2)

Tim-AIII→HSP90PER2→HSP90

co chaperone (1)

FKBP5→HSP90

expressed in (3)

APP→HSP90HSP90→SOD1HSP90→NLRP3

expresses (5)

HSP90→NFKBHSP90→TAUHSP90→P2RX7AMPK→HSP90HSP90→MICROGLIA

implicated in (1)

HSP90→Alzheimer'S Disease

inhibits (5)

17-AAG→HSP90HSP90→STINGHSP90→RAGEAMPK→HSP90HSP90→UNFOLDED PROTEIN RESPONSE

interacts with (2)

HSP90→GPX4HSP90→TAU

mediates (1)

HSP90→protein folding

modulates (1)

HSP90→protein folding

prevents (1)

HSP90→tau degradation

promotes (1)

HSP90→GPX4

regulates (7)

HSP90→proteostasisHSP90→ProteostasisHSP90→NLRP3HSP90→SLC6A4HSP90→TNF
▸ Show 2 more

stabilizes (1)

HSP90→tau stability

suppresses (1)

HSP90→protein aggregation

targets (5)

HSP90→STAT3CAT→HSP90DRD2→HSP90HSP90→MMP9HSP90→VEGF
🕑 Activity Feed
✏ update on knowledge_gap by max_gmail 2026-04-26T18:31
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