gene

MYO5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYO5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

11Outgoing

2Incoming

0Experiments

0Debates

Summary

MYO5A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in. Associated with Melanoma, Tumor. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MYO5A
Full Name	Myosin Va
Chromosome	15q21.2.
Function	encodes an unconventional myosin motor protein that moves towards the plus end of actin filaments.
Primary Expression	a tissue-specific manner, with highest levels in brain, melanocytes, and platelets
Molecular Weight	205 kDa
Amino Acids	855 aa
Ensembl ID	ENSG00000128594
GeneCards	MYO5A
Human Protein Atlas	MYO5A
Processive movement	Can traverse >1 μm on actin filaments without detachment
Step size	Takes ~36 nm steps, matching actin filament periodicity
Velocity	Moves at ~300-500 nm/s in vitro
Direction	Plus-end directed (towards actin filament barbed ends)
Regulation	Calmodulin binding modulates motor activity in response to calcium
Associated Diseases	neurodegeneration
Interactions	CDKN2A, DNA, KIF5B, LMNA, MYC, NCOA4
KG Connections	13 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MYO5A — Myosin Va

gene · 1340 words

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MYO5A Protein

protein · 1556 words

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Pathway Diagram

graph TD
    MYO5A["MYO5A"]
    Tumor{"Tumor"}
    MYO5A -->|"interacts_with"| Tumor
    Melanoma{"Melanoma"}
    MYO5A -->|"interacts_with"| Melanoma
    NCOA4["NCOA4"]
    MYO5A -->|"interacts_with"| NCOA4
    CDKN2A["CDKN2A"]
    MYO5A -->|"interacts_with"| CDKN2A
    RET["RET"]
    MYO5A -->|"interacts_with"| RET
    LMNA["LMNA"]
    MYO5A -->|"interacts_with"| LMNA
    KIF5B["KIF5B"]
    MYO5A -->|"interacts_with"| KIF5B
    P16["P16"]
    MYO5A -->|"interacts_with"| P16
    DNA["DNA"]
    MYO5A -->|"interacts_with"| DNA
    OPTN["OPTN"]
    MYO5A -->|"interacts_with"| OPTN
    MYC["MYC"]
    MYO5A -->|"interacts_with"| MYC
    neurodegeneration["neurodegeneration"]
    MYO5A -->|"implicated_in"| neurodegeneration

Outgoing (11)

Target	Relation	Type	Str
Tumor	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
P16	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NCOA4	interacts_with	gene	0.60
CDKN2A	interacts_with	gene	0.60
RET	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
KIF5B	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
genes-myo5a	linked_to	wiki_page	1.00
genes-myo5a	describes	wiki	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MYO5A in their description or question text

No additional research found