| Gene Symbol | MYO5A |
| Full Name | Myosin Va |
| Chromosome | 15q21.2. |
| Function | encodes an unconventional myosin motor protein that moves towards the plus end of actin filaments. |
| Primary Expression | a tissue-specific manner, with highest levels in brain, melanocytes, and platelets |
| Molecular Weight | 205 kDa |
| Amino Acids | 855 aa |
| Ensembl ID | ENSG00000128594 |
| GeneCards | MYO5A |
| Human Protein Atlas | MYO5A |
| Processive movement | Can traverse >1 μm on actin filaments without detachment |
| Step size | Takes ~36 nm steps, matching actin filament periodicity |
| Velocity | Moves at ~300-500 nm/s in vitro |
| Direction | Plus-end directed (towards actin filament barbed ends) |
| Regulation | Calmodulin binding modulates motor activity in response to calcium |
| Associated Diseases | neurodegeneration |
| Interactions | CDKN2A, DNA, KIF5B, LMNA, MYC, NCOA4 |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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