gene

GATA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GATA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

20Outgoing

11Incoming

0Experiments

0Debates

Summary

GATA1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with Cancer, Carcinoma, Tumor. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GATA1
Full Name	GATA Binding Protein 1
Aliases	Page for GATA1
Function	GATA1 belongs to the GATA family of transcription factors characterized by conserved zinc finger domains that bind the DNA sequence (A/T)GATA(A/G).
Pathways	Apoptosis, Cell Cycle
Ensembl ID	ENSG00000102145
GeneCards	GATA1
Human Protein Atlas	GATA1
Associated Diseases	neurodegeneration
Interactions	APOPTOSIS, CANCER, CREBBP, GATA2, GENES, HSP70
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GATA1 - GATA Binding Protein 1

gene · 913 words

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Pathway Diagram

graph TD
    GATA1["GATA1"]
    AGGF1["AGGF1"]
    GATA1 -->|"upregulates"| AGGF1
    Carcinoma{"Carcinoma"}
    GATA1 -->|"interacts with"| Carcinoma
    Cancer{"Cancer"}
    GATA1 -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    GATA1 -->|"interacts with"| Tumor
    HSP70["HSP70"]
    GATA1 -->|"activates"| HSP70
    APOPTOSIS["APOPTOSIS"]
    GATA1 -->|"therapeutic target"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    GATA1 -->|"therapeutic target"| Apoptosis
    MYC["MYC"]
    GATA1 -->|"interacts with"| MYC
    CANCER["CANCER"]
    GATA1 -->|"interacts with"| CANCER
    GATA1 -->|"interacts with"| APOPTOSIS
    CREBBP["CREBBP"]
    GATA1 -->|"interacts with"| CREBBP
    IL6ST["IL6ST"]
    GATA1 -->|"interacts with"| IL6ST
    SNCA["SNCA"]
    SNCA -->|"contributes to"| GATA1
    P53["P53"]
    P53 -->|"activates"| GATA1
    LRP1["LRP1"]
    LRP1 -->|"interacts with"| GATA1
    NR3C1["NR3C1"]
    NR3C1 -->|"interacts with"| GATA1
    style GATA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
Tumor	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
GATA2	activates	gene	0.60
ST3GAL2	activates	gene	0.60
ST8SIA1	activates	gene	0.60
CANCER	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
RUNX1	activates	gene	0.60
NR3C1	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
HSP70	activates	gene	0.60
Apoptosis	interacts_with	pathway	0.60
Cell Cycle	interacts_with	pathway	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
MYC	interacts_with	gene	0.60
CREBBP	interacts_with	gene	0.60
IL6ST	interacts_with	gene	0.60
GATA2	co_expressed_with	gene	0.50

Incoming (11)

Source	Relation	Type	Str
genes-gata1	documents	wiki	1.00
genes-gata1	describes	wiki	1.00
SNCA	contributes_to	gene	0.80
APOPTOSIS	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
IL6ST	interacts_with	gene	0.60
MYC	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
NR3C1	interacts_with	gene	0.60
CREBBP	interacts_with	gene	0.60
P53	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GATA1 in their description or question text

No additional research found