gene

ADRA1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADRA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

17Outgoing

8Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ADRA1A
Chromosome	8p21.2 [@zhang2020]
Protein Type	Gene
Function	is a gene encoding the alpha-1A adrenergic receptor (ADRA1A), a member of the G protein-coupled receptor (GPCR) superfamily.
Amino Acids	466 aa
Exons	6
Pathways	MAPK Pathway
UniProt ID	P35348
NCBI Gene ID	148
Ensembl ID	ENSG00000120907
GeneCards	ADRA1A
Human Protein Atlas	ADRA1A
Extracellular Domain	Contains ligand-binding sites for catecholamines (epinephrine, norepinephrine)
Transmembrane Domains (7)	Form the receptor core and G protein coupling interface
Intracellular Loops	Interface with G proteins (primarily Gq/11) and β-arrestins
Associated Diseases	ALS
Interactions	ADRA1B, ADRA2A, ADRB1, DBH, DRD1, DRD2
KG Connections	25 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADRA1A Gene

gene · 1073 words

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Pathway Diagram

graph TD
    ADRA1A["ADRA1A"] -->|"activates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADRA1A["ADRA1A"] -->|"activates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADRA1A["ADRA1A"] -->|"activates"| HRH1["HRH1"]
    style HRH1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ADRA1A["ADRA1A"] -->|"activates"| GRIN1["GRIN1"]
    style GRIN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ADRA1A["ADRA1A"] -->|"activates"| HCRTR1["HCRTR1"]
    style HCRTR1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ADRA1A["ADRA1A"] -->|"activates"| Epigenetic["Epigenetic"]
    style Epigenetic fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ADRA1A["ADRA1A"] -->|"activates"| Dna_Methylation["Dna Methylation"]
    style Dna_Methylation fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DRD2["DRD2"] -->|"activates"| ADRA1A["ADRA1A"]
    style DRD2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HRH3["HRH3"] -->|"activates"| ADRA1A["ADRA1A"]
    style HRH3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    HCRTR2["HCRTR2"] -->|"activates"| ADRA1A["ADRA1A"]
    style HCRTR2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ADRA1B["ADRA1B"] -->|"activates"| ADRA1A["ADRA1A"]
    style ADRA1B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DRD1["DRD1"] -->|"activates"| ADRA1A["ADRA1A"]
    style DRD1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ADRA1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADRA1A	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Ms	activates	disease	0.65
Als	activates	disease	0.65
HCRTR1	activates	gene	0.60
HRH1	activates	gene	0.60
Dna Methylation	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
GRIN1	activates	gene	0.60
ADRA2A	interacts_with	gene	0.60
ALS	associated_with	disease	0.60
ADRB1	interacts_with	gene	0.60
ERBB4	interacts_with	gene	0.60
IL1RL1	interacts_with	gene	0.60
IL33	interacts_with	gene	0.60
NRG1	interacts_with	gene	0.60
DBH	interacts_with	gene	0.60

Incoming (8)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADRA1A	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
DRD2	activates	gene	0.60
HRH3	activates	gene	0.60
HCRTR2	activates	gene	0.60
ADRA1B	activates	gene	0.60
DRD1	activates	gene	0.60
GRIA1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ADRA1A in their description or question text

No additional research found