Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YKL-40: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | YKL |
| Chromosome | 1q32.1 |
| Function | YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020]. |
| GeneCards | YKL |
| Human Protein Atlas | YKL |
| Associated Diseases | Alzheimer's disease |
| Interactions | C3, CHI3L1, GFAP, IL-6, TET2, TREM2 |
| KG Connections | 53 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
YKL_40["YKL-40"]
Astrocytes["Astrocytes"]
YKL_40 -->|"expressed_in"| Astrocytes
Alzheimer_s_Disease{"Alzheimer's Disease"}
YKL_40 -->|"involved_in"| Alzheimer_s_Disease
Cerebrospinal_Fluid["Cerebrospinal Fluid"]
YKL_40 -->|"expressed_in"| Cerebrospinal_Fluid
Neuroinflammation["Neuroinflammation"]
YKL_40 -->|"regulates"| Neuroinflammation
ALZHEIMER(["ALZHEIMER"])
YKL_40 -->|"regulates"| ALZHEIMER
Alzheimer_S_Disease{"Alzheimer'S Disease"}
YKL_40 -->|"regulates"| Alzheimer_S_Disease
CHI3L1(["CHI3L1"])
CHI3L1 -->|"encodes"| YKL_40
CLOCK(["CLOCK"])
CLOCK -->|"regulates"| YKL_40
style YKL_40 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Astrocytes | expressed_in | cell_type | 0.95 |
| Alzheimer'S Disease | biomarker_for | disease | 0.95 |
| Aging | correlates_with | process | 0.90 |
| Alzheimer's Disease | involved_in | disease | 0.90 |
| Alzheimer's Disease | biomarker_for | disease | 0.90 |
| Cerebrospinal Fluid | expressed_in | cell_type | 0.90 |
| neuroinflammation | biomarker_for | disease | 0.85 |
| neuroinflammation | activates | disease | 0.85 |
| Neuroinflammation | regulates | process | 0.85 |
| Alzheimer'S Disease Progression | risk_factor_for | phenotype | 0.85 |
| microglia | expressed_in | cell_type | 0.75 |
| astrogliosis | indicates | mechanism | 0.70 |
| astrocytes | expressed_in | cell_type | 0.65 |
| oxidative stress response | participates_in | pathway | 0.65 |
| DAM microglia | expressed_in | cell_type | 0.65 |
| neurons | expressed_in | cell_type | 0.55 |
| neuroinflammation | regulates | disease | 0.55 |
| Alzheimer's disease | associated_with | disease | 0.55 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
| neurotrophin signaling | participates_in | pathway | 0.55 |
| ALZHEIMER | regulates | gene | 0.50 |
| Alzheimer'S Disease | regulates | disease | 0.50 |
| Astrocyte | regulates | cell_type | 0.50 |
| disease | regulates | disease | 0.50 |
| ALZHEIMER'S | regulates | concept | 0.50 |
| aging | activates | phenotype | 0.50 |
| CEREBROSPINAL FLUID | activates | concept | 0.50 |
| NEUROFILAMENT LIGHT CHAIN | associated_with | protein | 0.50 |
| SNAP-25 | associated_with | protein | 0.50 |
| NEUROGRANIN | associated_with | protein | 0.50 |
| SYNUCLEIN | associated_with | concept | 0.50 |
| α-SYNUCLEIN | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CHI3L1 | encodes | gene | 0.95 |
| 40991070 | correlates with | paper | 0.90 |
| GFAP | biomarker_for | gene | 0.75 |
| GFAP | activates | gene | 0.65 |
| TNF | biomarker_for | gene | 0.65 |
| TREM2 | biomarker_for | gene | 0.65 |
| IL-6 | activates | gene | 0.55 |
| TET2 | activates | gene | 0.55 |
| G3BP1 | regulates | gene | 0.55 |
| IL-6 | regulates | gene | 0.55 |
| C3 | activates | gene | 0.55 |
| TREM2 | activates | gene | 0.55 |
| BDNF | protects_against | gene | 0.55 |
| GDNF | protects_against | gene | 0.55 |
| IL-6 | biomarker_for | gene | 0.55 |
| Neuroinflammation | regulates | process | 0.50 |
| CLOCK | regulates | gene | 0.50 |
| CHI3L1 | regulates | protein | 0.50 |
| CHI3L1 | activates | protein | 0.50 |
| CHI3L1 | associated_with | protein | 0.50 |
| CHI3L1 | inhibits | protein | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| Neuroinflammation | associated_with | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2, | 0.757 | biomarkers | What biomarkers can reliably detect micr |
| CSF YKL-40 as a Priming-Specific Chitinase Marker | 0.714 | biomarkers | What biomarkers can reliably detect micr |
| Dynamic Blood-Based Exosome Panel for Real-Time Neuroinflamm | 0.000 | biomarkers | What biomarkers can reliably detect micr |
| Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining | 0.000 | biomarkers | What biomarkers can reliably detect micr |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.500
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning YKL-40 in their description or question text
No additional research found