protein 619 words KG: VPS16
Contents

VPS16 Protein

🔬 Protein Info
Gene SymbolVPS16
Full NameVacuolar Protein Sorting 16 Homolog
Chromosome20q13.33
FunctionIn neurons, VPS16 and the HOPS complex play essential roles in
Molecular Weight89 kDa
Amino Acids790 aa
UniProt IDQ9H269
NCBI Gene ID64601
Ensembl IDENSG00000112357
GeneCardsVPS16
Human Protein AtlasVPS16
HOPS ComplexMulti-subunit tethering complex containing VPS11, VPS18, VPS33
Rab7 GTPaseKey effector of VPS16-mediated trafficking
Autophagy-Lysosomal PathwayVPS16-dependent
Associated Diseasescolorectal cancer, dystonia
InteractionsAND, ATP, LC3, LYSOSOME, Ras, STX17
KG Connections25 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (4)

Autophagosome Maturation Checkpoint Control
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with
COX15 — Cytochrome C Oxidase Assembly Factor 15
gene · KG edge: associated_with
MAP1LC3A Gene
gene · KG edge: inhibits

Knowledge Graph (12 edges)

VPS33A inhibits VPS16
STX17 inhibits VPS16
UVRAG interacts_with VPS16
VPS16 inhibits LC3
VPS16 component_of HOPS
VPS16 causes dystonia
VPS16 associated_with colorectal cancer
VPS16 component_of CORVET
VPS16 inhibits VPS33A
VPS16 interacts_with UVRAG

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