Contents

Vesicular Monoamine Transporter 2 (VMAT2) Pathway in Parkinson's Disease

🔬 Protein Info

Gene Symbol	ent-gene-62458d07
Energy Coupling	Uses V-ATPase-generated proton gradient (H+ influx drives monoamine efflux)
Substrate Specificity	Transports dopamine, serotonin, norepinephrine, epinephrine, histamine, and trace amines
Stoichiometry	Typically 2 monoamine molecules transported per proton
Vesicular Loading	Achieves concentrations 10-100 fold higher in vesicles than in cytoplasm
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

20534840 segregates partially from ent-gene-62458d07

20534840 shows more dispersion along ent-gene-62458d07

20534840 shows less availability for ent-gene-62458d07