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gene 706 words KG: VMAT2
Contents

VMAT2 Gene

🧬 Gene Info
Gene SymbolVMAT2
Full NameVesicular Monoamine Transporter 2
Chromosome10q25.2
FunctionVMAT2 mediates vesicular uptake of monoamines
Primary Expressionall monoaminergic neurons (dopaminergic, serotonergic, noradrenergic)
Molecular Weight56 kDa
Amino Acids525 aa
Exons18
PathwaysAutophagy, Mapk, Mtor
NCBI Gene ID6844
Ensembl IDENSG00000165646
OMIM193001
GeneCardsVMAT2
Human Protein AtlasVMAT2
Associated DiseasesParkinson's disease
Known Drugs/Compoundslevodopa
InteractionsALPHA-SYNUCLEIN, AMPK, AUTOPHAGY, DAT, MTOR, NEUROINFLAMMATION
KG Connections28 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38CYP46A1 Overexpression Gene Therapy
Score: 0.92Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.60

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Parkinson Basal Ganglia Circuit
circuit · KG edge: activatesNeuRon Therapeutics
company · KG edge: activatesNeuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: activatesNeurodegeneration
disease · KG edge: implicated_inAMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

NURR1 activates VMAT2
VMAT2 activates MTOR
AADC regulates VMAT2
NURR1 regulates VMAT2
TH regulates VMAT2
levodopa targets VMAT2
genes-vmat2 documents VMAT2
AUTOPHAGY activates VMAT2
PARKINSON'S DISEASE activates VMAT2
AMPK activates VMAT2

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