| Gene Symbol | TRPM8 |
| Full Name | TRPM8 Protein |
| Aliases | Transient Receptor Potential Cation Channel Subfamily M Member 8 |
| Chromosome | 2q37 |
| Protein Type | Receptor |
| Function | TRPM8 encodes the Transient Receptor Potential Melastatin 8 channel, a non-selective calcium-permeable cation channel activated by cold temperatures (below 25°C), menthol, and other cooling agents. |
| Primary Expression | a subset of sensory neurons (cold-sensitive dorsal root ganglion and trigeminal ganglion neurons) and in some central neurons |
| Subcellular Localization | </strong></td><td>Plasma membrane</td></tr> |
| Molecular Weight | 110 kDa |
| Amino Acids | 1104 aa |
| Pathways | Adaptive Immunity |
| UniProt ID | [Q7Z2W7](https://www.uniprot.org/uniprot/Q7Z2W7) |
| Ensembl ID | ENSG00000164189 |
| OMIM | 607687 |
| GeneCards | TRPM8 |
| Human Protein Atlas | TRPM8 |
| Associated Diseases | neurodegeneration |
| Interactions | TAC1, TNFA, TRPA1, WNT3A |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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