concept

TAU HYPERPHOSPHORYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU HYPERPHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

3Analyses

16Outgoing

48Incoming

0Experiments

4Debates

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💡 Concept Info

Name	TAU HYPERPHOSPHORYLATION

Pathway Diagram

graph TD
    TAU_HYPERPHOSPHORYLATION["TAU HYPERPHOSPHORYLATION"]
    TAU_HYPERPHOSPHORYLATION -->|"contributes to"| Tau_Aggregation["Tau Aggregation"]
    TAU_HYPERPHOSPHORYLATION -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    MAPT["MAPT"] -->|"involved_in"| TAU_HYPERPHOSPHORYLATION
    Exendin_4["Exendin-4"] -->|"inhibits"| TAU_HYPERPHOSPHORYLATION
    ASK1["ASK1"] -->|"causes"| TAU_HYPERPHOSPHORYLATION
    Wnt___catenin_NeuroD1_Pathway["Wnt/beta-catenin/NeuroD1 Pathway"] -->|"regulates"| TAU_HYPERPHOSPHORYLATION
    Neuroinflammation["Neuroinflammation"] -->|"contributes to"| TAU_HYPERPHOSPHORYLATION
    HEPATOKINES["HEPATOKINES"] -->|"regulates"| TAU_HYPERPHOSPHORYLATION

Outgoing (16)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Neurofibrillary Tangles	causes	biomarker	0.95
Cognitive Impairments	associated_with	phenotype	0.90
Alzheimer'S Disease	biomarker_for	disease	0.90
Tauopathies	biomarker_for	disease	0.90
Neurodegeneration	contributes_to	process	0.90
Alzheimer's Disease	drives	disease	0.90
Paired Helical Filaments	causes	biomarker	0.90
Synaptic Toxicity	associated_with	phenotype	0.90
Alzheimer'S Disease	contributes_to	disease	0.85
Tau Aggregation	contributes_to	process	0.85
Type 2 Diabetes	associated_with	disease	0.85
tau O-GlcNAc protection	suppresses	process	0.85
Alzheimer's disease	causes	disease	0.70
Alzheimer's disease	causes	disease	0.70
Alzheimer's disease	associated_with	disease	0.70

Incoming (48)

Source	Relation	Type	Str
MAPT	involved_in	protein	0.95
PPP2CA	regulates	gene	0.95
GSK3B	involved_in	gene	0.95
DAB	causes	compound	0.95
PKR	causes	entity	0.90
32057125	is associated with	paper	0.90
32057125	is an early step in and associated with	paper	0.90
Ampk Activation	promotes	process	0.90
Sulforaphane	inhibits	compound	0.90
Aβ oligomers	triggers	biomarker	0.90
31931119	induces	paper	0.90
GSK3B	causes	protein	0.90
CDK5	causes	protein	0.90
Air Pollution	causes	compound	0.90
MAPT MUTATION	causes	gene	0.90
Exendin-4	inhibits	drug	0.90
37435081	ameliorated	paper	0.90
32057125	is an early step in	paper	0.90
Platelets	associated_with	cell_type	0.85
ASK1	mediates	protein	0.85
Tau Kinase Inhibitors	inhibits	drug	0.85
Wnt/β-catenin/NeuroD1 Pathway	regulates	pathway	0.85
APOE4	risk_factor_for	gene	0.85
Ceramide	contributes_to	compound	0.85
MTOR	promotes	gene	0.85
ASK1	causes	protein	0.85
Neuroinflammation	contributes_to	process	0.80
miR-125b	contributes_to	biomarker	0.80
GSK3B	mediates	gene	0.80
Insulin Signaling	inhibits	pathway	0.80
HEPATOKINES	regulates	protein	0.80
miR-132	inhibits	biomarker	0.80
ASK1	contributes_to	protein	0.80
GSK3β	activates	protein	0.70
MTOR	activates	protein	0.70
CDK5	causes	protein	0.70
GSK3β	causes	protein	0.70
mTOR	activates	protein	0.70
Ramalin	suppresses	gene	0.70
BACE1	causes	gene	0.70
PI3K	inhibits	gene	0.70
BMAL1	protects_against	gene	0.70
Exendin-4	inhibits	drug	0.70
Indoles	protects_against	process	0.70
GSK-3	regulates	protein	0.70
SLC1A2	contributes_to	gene	0.60
37435081	is responsible for	paper	0.60
AKT	regulates	gene	0.60