entity

Aβ oligomers

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Aβ oligomers: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

1Hypotheses

3Analyses

9Outgoing

5Incoming

0Experiments

4Debates

No AI portrait yet

Outgoing (9)

Target	Relation	Type	Str
tau hyperphosphorylation	triggers	mechanism	0.90
microglia	activates	cell_type	0.90
Hippocampal Neuronal Damage	causes	phenotype	0.85
SPP1	causes	gene	0.70
Perivascular macrophages	activates	cell_type	0.70
SPP1 upregulation	causes	process	0.70
C1q/C3/CR3 upregulation	causes	mechanism	0.70
CD36	activates	protein	0.50
YAP/TAZ nuclear translocation	causes	process	0.50

Incoming (5)

Source	Relation	Type	Str
30867420	reduce	paper	0.90
24713000	impair	paper	0.90
24713000	cause	paper	0.90
30867420	induce	paper	0.60
CD36	regulates	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.716	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (3)

Scientific analyses that reference this entity

Clinical Trial Landscaping for Alzheimer's Disease Therapeutics

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667]	Zhang D, Zhang W, Ming C, Gao X, Yuan H,	Neuron	2024
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117]	Balusu S, De Strooper B	Acta neuropathologica	2024
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890]	Burillo J, Marqués P, Jiménez B, Gonzále	Cells	2021
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169]	["Oakley, Holly", "Cole, Sarah L", "Loga	The Journal of neuroscience :	2006
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773]	["Hardy, John", "Selkoe, Dennis J"]	Science (New York, N.Y.)	2002

Debates (4)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

closed · Rounds: 4 · Score: 0.68 · 2026-04-22

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

What is the current clinical trial landscape for AD therapeutics, and which mech

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Is the amyloid concentration in AD clinical trials rational given lecanemab's ap

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning Aβ oligomers in their description or question text

No additional research found