Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAB2A7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MAB2A7 |
graph TD
MAB2A7["MAB2A7"]
MAB2A7 -->|"reduces"| tau_pathology["tau pathology"]
MAB2A7 -->|"blocks"| neuronal_loss["neuronal loss"]
MAB2A7 -->|"targets"| p_tau217["p-tau217"]
MAB2A7 -->|"targets"| P_Tau217["P-Tau217"]
MAB2A7 -->|"inhibits"| Neuronal_Loss["Neuronal Loss"]
MAB2A7 -->|"treats"| Cognitive_Deficits["Cognitive Deficits"]
MAB2A7 -->|"treats"| Brain_Atrophy["Brain Atrophy"]| Target | Relation | Type | Str |
|---|---|---|---|
| p-tau217 | targets | biomarker | 0.98 |
| Tau Pathology | associated_with | process | 0.95 |
| P-Tau217 | targets | biomarker | 0.95 |
| Neuronal Loss | inhibits | process | 0.92 |
| Brain Atrophy | treats | phenotype | 0.90 |
| tau pathology/aggregation | reduces | process | 0.90 |
| apoptosis-associated neuronal loss | blocks | process | 0.90 |
| Cognitive Deficits | treats | phenotype | 0.90 |
| Tau Pathology | associated_with | process | 0.90 |
| Neuronal Loss | inhibits | process | 0.90 |
| Cognitive Deficits | treats | phenotype | 0.90 |
| Synaptic Function | modulates | process | 0.85 |
| Synaptic Function | associated_with | process | 0.80 |
| Alzheimer's disease | treats | disease | 0.70 |
| neuronal loss | protects_against | process | 0.70 |
| p-tau217 | inhibits | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MAB2A7 in their description or question text
No additional research found