protein

SYNAPSIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPSIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

6Outgoing

4Incoming

0Experiments

0Debates

Summary

Synapsin-1 is a neuronal phosphoprotein encoded by SYN1 that regulates synaptic vesicle clustering, neurotransmitter release, and serves as a biomarker of synaptic integrity in AD and PD.

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🔬 Protein Info

Gene Symbol	SYNAPSIN
Function	regulates synaptic vesicle clustering
Molecular Weight	74 kDa
Amino Acids	705 aa
Pathways	MAPK
GeneCards	SYNAPSIN
Human Protein Atlas	SYNAPSIN
Interactions	BDNF, PSD95, TRKB
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["SYNAPSIN-1"]
    N1["PSD95"]
    N0 -->|"activates"| N1
    N2["Neurogenesis"]
    N0 -->|"activates"| N2
    N3["Hippocampus"]
    N0 -->|"activates"| N3
    N4["DENDRITIC SPINE"]
    N0 -->|"activates"| N4
    N5["oxidative stress"]
    N0 -->|"inhibits"| N5
    N6["Genes"]
    N0 -->|"inhibits"| N6
    N7["BDNF"]
    N7 -->|"activates"| N0
    N8["TRKB"]
    N8 -->|"activates"| N0
    N9["mTOR"]
    N9 -->|"activates"| N0
    N7 -->|"inhibits"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 pathway
    class N7 gene
    class N8 gene

Outgoing (6)

Target	Relation	Type	Str
Synaptic Function	involved_in	process	0.80
PSD95	activates	gene	0.50
Neurogenesis	activates	pathway	0.50
Hippocampus	activates	entity	0.50
DENDRITIC SPINE	activates	concept	0.50
oxidative stress	inhibits	phenotype	0.50

Incoming (4)

Source	Relation	Type	Str
BDNF	activates	gene	0.50
TRKB	activates	gene	0.50
mTOR	activates	entity	0.50
BDNF	inhibits	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SYNAPSIN-1 in their description or question text

No additional research found