gene 936 words KG: SEMA3F
Contents

SEMA3F Gene

🧬 Gene Info
Gene SymbolSEMA3F
Full NameSemaphorin 3F
Chromosome3p21.31
Functionencodes a secreted axonal guidance molecule critical for neuronal development, synaptic organization, and vascular patterning.
Amino Acids810 aa
PathwaysAmyloid, Epigenetic
UniProt ID[Q13241](https://www.uniprot.org/uniprot/Q13241)
Ensembl IDENSG00000061656
GeneCardsSEMA3F
Human Protein AtlasSEMA3F
Associated Diseasesneurodegeneration
InteractionsActin, AMYLOID, APOE, APOE3, APOE4, App
KG Connections47 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (9)

Neurodegeneration
disease · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
LRP5 — Low Density Lipoprotein Receptor-Related Protein
gene · KG edge: associated_with
nrp1
gene · KG edge: binds

Knowledge Graph (12 edges)

SEMA3F inhibits PI3K-Akt-mTOR
SEMA3F upregulates Neutrophils
SEMA3F downregulates AKT
SEMA3F downregulates STAT3
SEMA3F downregulates HIF-1alpha
SEMA3F downregulates VEGF
SEMA3F inhibits mTOR Signaling
LRP5 associated_with SEMA3F
APOE activates SEMA3F
LRP1 associated_with SEMA3F

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.