gene

RGS5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

13Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for RGS5 — Regulator of G Protein Signaling 5

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	RGS5
Full Name	Regulator of G Protein Signaling 5
Chromosome	1q23.3
Function	By accelerating GTP hydrolysis on Gαq subunits, RGS5 terminates signaling from vasoconstrictor receptors including angiotensin II (AT1R), endothelin-1 (ETA), and α1-adrenergic receptors.
Primary Expression	Vascular smooth muscle cells, Pericytes, Brain vasculature
Amino Acids	177 aa
UniProt ID	Q9NZH6
NCBI Gene ID	6053
Ensembl ID	ENSG00000143248
OMIM	607073
GeneCards	RGS5
Human Protein Atlas	RGS5
Interactions	CRH, EPILEPSY, INFLAMMATION, PDGFRB, PENK, SST
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RGS5 — AlphaFold Q9NZH6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RGS5 — Regulator of G Protein Signaling 5

gene · 625 words

→

Pathway Diagram

graph TD
    RGS5["RGS5"]
    Inflammation{"Inflammation"}
    RGS5 -->|"activates"| Inflammation
    INFLAMMATION["INFLAMMATION"]
    RGS5 -->|"activates"| INFLAMMATION
    PDGFRB["PDGFRB"]
    RGS5 -->|"activates"| PDGFRB
    neurodegeneration["neurodegeneration"]
    RGS5 -->|"implicated in"| neurodegeneration
    COL1A1["COL1A1"]
    COL1A1 -->|"associated with"| RGS5
    style RGS5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
Epilepsy	inhibits	disease	0.65
INFLAMMATION	activates	gene	0.60
Neuron	inhibits	cell_type	0.60
Astrocyte	associated_with	cell_type	0.60
PENK	inhibits	gene	0.60
PDGFRB	activates	gene	0.60
PVALB	expressed_in	gene	0.60
SST	inhibits	gene	0.60
EPILEPSY	inhibits	gene	0.60
Albumin	associated_with	protein	0.60
App	associated_with	protein	0.60
pericytes	expressed_in	cell_type	0.55

Incoming (8)

Source	Relation	Type	Str
CRH	inhibits	gene	0.60
PVALB	associated_with	gene	0.60
SST	inhibits	gene	0.60
PENK	inhibits	gene	0.60
COL1A1	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
EPILEPSY	inhibits	gene	0.60
RNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RGS5 in their description or question text

No additional research found