protein

PLK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

13Outgoing

18Incoming

0Experiments

0Debates

Summary

Page for PLK4 Protein

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🔬 Protein Info

Gene Symbol	PLK4
Full Name	Polo-Like Kinase 4
Chromosome	4q28.1
Protein Type	Kinase
Function	is a serine/threonine protein kinase that serves as the master regulator of centriole duplication, playing a critical role in microtubule organization, ciliogenesis, and cell cycle progression.
Primary Expression	the central nervous system:
Molecular Weight	97 kDa
Ensembl ID	ENSG00000142792
GeneCards	PLK4
Human Protein Atlas	PLK4
Centrioles	Cylindrical structures (9 triplet microtubules)
Pericentriolar material (PCM)	Protein matrix
Centrin	Calcium-binding protein
Nexin	Linker proteins
MCPH1	DNA damage response
Associated Diseases	Alzheimer, Parkinson
Interactions	FCGRT, KAT2A
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLK4["PLK4"]
    Alzheimer["Alzheimer"]
    PLK4 -->|"therapeutic target"| Alzheimer
    Parkinson["Parkinson"]
    PLK4 -->|"therapeutic target"| Parkinson
    Alzheimer["Alzheimer"]
    PLK4 -->|"associated with"| Alzheimer
    Parkinson["Parkinson"]
    PLK4 -->|"associated with"| Parkinson
    FCGRT["FCGRT"]
    PLK4 -->|"associated with"| FCGRT
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PLK4 -->|"associated with"| PARKINSON_S_DISEASE
    PI3K["PI3K"]
    PLK4 -->|"associated with"| PI3K
    CASP3["CASP3"]
    CASP3 -->|"therapeutic target"| PLK4
    STAT3["STAT3"]
    STAT3 -->|"therapeutic target"| PLK4
    PARKINSON["PARKINSON"]
    PARKINSON -->|"therapeutic target"| PLK4
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"therapeutic target"| PLK4
    GENES["GENES"]
    GENES -->|"associated with"| PLK4
    AKT["AKT"]
    AKT -->|"associated with"| PLK4
    FCGRT["FCGRT"]
    FCGRT -->|"associated with"| PLK4
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| PLK4
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| PLK4
    STAT3["STAT3"]
    STAT3 -->|"associated with"| PLK4
    RAGE["RAGE"]
    RAGE -->|"associated with"| PLK4
    AND["AND"]
    AND -->|"associated with"| PLK4
    CASP3["CASP3"]
    CASP3 -->|"associated with"| PLK4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| PLK4
    neurodegeneration["neurodegeneration"]
    PLK4 -->|"implicated in"| neurodegeneration

Outgoing (13)

Target	Relation	Type	Str
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
PARKINSON'S DISEASE	associated_with	gene	0.60
FCGRT	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
Stat3	therapeutic_target	protein	0.60
Pi3K	therapeutic_target	protein	0.60
Akt	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
oxidative stress response	participates_in	pathway	0.60
FCGRT	interacts_with	concept	0.50

Incoming (18)

Source	Relation	Type	Str
KAT2A	regulates	gene	0.60
KAT2A	associated_with	gene	0.60
KAT2A	phosphorylates	gene	0.60
KAT2A	protects_against	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
FCGRT	interacts_with	gene	0.60
CASP3	therapeutic_target	gene	0.60
STAT3	therapeutic_target	gene	0.60
AKT	associated_with	gene	0.60
FCGRT	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
RAGE	associated_with	gene	0.60
CASP3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PLK4 in their description or question text

No additional research found