| Gene Symbol | PGRMC1 |
| Protein Type | Receptor |
| Function | is a heme-binding membrane protein that serves a. |
| Primary Expression | neurons and glial cells throughout the brain, including the cerebral cortex, [hippocampus](/brain-region |
| Subcellular Localization | </th><td>Endoplasmic reticulum, plasma membrane, nucleus</td></tr> |
| Molecular Weight | 21.6 kDa |
| GeneCards | PGRMC1 |
| Human Protein Atlas | PGRMC1 |
| Alzheimer's disease | PGRMC1 levels are altered in AD brain tissue, and it interacts with amyloid-beta processing machinery. Some evidence suggests it may protect against amyloid-beta induced toxicity[@cai2020] |
| Parkinson's disease | PGRMC1 expression is modified in PD models, and its neuroprotective properties may be relevant to dopaminergic neuron survival[@gatto2015] |
| Aging | Age-related changes in PGRMC1 expression may contribute to reduced cellular resilience in the aging brain[@liu2021] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!