Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Learning And Memory | involved_in | process | 0.90 |
| Neuroprotection | mediates | process | 0.90 |
| NEURON | protects_against | cell_type | 0.80 |
| Neurons | modulates | cell_type | 0.75 |
| Astrocytes | modulates | cell_type | 0.75 |
| NEURONS | causes | cell_type | 0.64 |
| ASTROCYTES | causes | cell_type | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIAL CELL | produces | cell_type | 0.80 |
| DHT | inhibits | compound | 0.80 |
| MICROGLIA | activates | cell_type | 0.64 |
| PLGF | activates | protein | 0.56 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia | clinical | dementia with behavioral and p | 0.950 | 0.00 | human patients | proposed | N/A |
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Mechanism: Why Does Amyloid Removal Only Slow Decline 27%? | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| cGAS-STING Pathway Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Microglial Aging and Immune Memory in Neurodegeneration — Training the | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Microglial Contributions to Huntington's Disease Pathogenesis | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NLRP3 Inflammasome Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Levodopa-Induced Dyskinesias Mechanism — Experiment Design | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the S [PMID:37738560] | Justice JN, Leng XI, LeBrasseur NK, Tchk | J Gerontol A Biol Sci Med Sci | 2024 | 1 |
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] | Maxine R Nelson, Peng Liu, Ayushi Agrawa | Nature neuroscience | 2023 | 1 |
| Sex differences in autophagy-mediated diseases: toward precision medicine. [PMID:32264724] | Shang D, Wang L, Klionsky DJ, Cheng H, Z | Autophagy | 2021 | 1 |
| Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populatio [PMID:33144684] | He D, Wang D, Lu P, Yang N, Xue Z, Zhu X | Oncogene | 2021 | 1 |
| A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell re [PMID:31488706] | Packer JS, Zhu Q, Huynh C, Sivaramakrish | Science | 2019 | 1 |
| Metabolic asymmetry and the global diversity of marine predators. [PMID:30679341] | Grady JM, Maitner BS, Winter AS, Kaschne | Science | 2019 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? [PMID:28224793] | Wang Z, DeWitt JC, Higgins CP, Cousins I | Environ Sci Technol | 2017 | 1 |
| Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells [PMID:26657143] | Chang J, Wang Y, Shao L, Laberge RM, Dem | Nat Med | 2016 | 1 |
| Gene Expression by Mouse Inner Ear Hair Cells during Development. [PMID:25904789] | Scheffer DI, Shen J, Corey DP, Chen ZY | J Neurosci | 2015 | 1 |
| The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. [PMID:25754370] | Zhu Y, Tchkonia T, Pirtskhalava T, Gower | Aging Cell | 2015 | 1 |
| Chapter 6: Structural variation and medical genomics. [PMID:23300412] | Raphael BJ | PLoS Comput Biol | 2012 | 1 |
| Caffeine and adenosine. [PMID:20164566] | Ribeiro JA, Sebastião AM | J Alzheimers Dis | 2010 | 1 |
| Senolytic elimination of therapy-induced senescent cells by ABT-263 improves che [PMID:41423036] | Zhang D, Zhu J, Zou R, Zhang H, Yu BP, L | Biochemical pharmacology | 2026 | 0 |
| Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635] | Thedim M, Hu J, Maher M, Wiener-Kronish | Br J Anaesth | 2026 | 0 |
| Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639] | Bae H, Song Z, Ali A, Sasaki T, Tesi N e | Geroscience | 2026 | 0 |
| Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401] | Stern A, Linial M | Geroscience | 2026 | 0 |
| Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-D [PMID:41503702] | Kim J, Park D, Yoo J, Kim JE, Kim EH et | Stroke | 2026 | 0 |
| Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227] | Samudra N, Vemuri M, Weitlauf J | Curr Opin Obstet Gynecol | 2026 | 0 |
| DPP4-regulated endothelial cell ferroptosis modulates atherosclerosis progressio [PMID:41565199] | Zheng L, Liang K, Peng Y, Jin M, Chen X | J Mol Cell Cardiol | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NO in their description or question text
Score: 0.770 · neurodegeneration · 2026-04-22
## Mechanistic Overview H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasis starts from th
Score: 0.742 · neurodegeneration · 2026-04-02
## Mechanistic Overview APOE4-Selective Lipid Nanoemulsion Therapy starts from the claim that modulating APOE within the
Score: 0.740 · protein folding · 2026-04-22
**Molecular Mechanism and Rationale** The therapeutic hypothesis centers on the kinetic constraints governing chaperone
Score: 0.740 · neurodegeneration · 2026-04-25
Transient Aβ exposure induces dendritic tau missorting that then converts into a locally self-propagating tau oligomer/s
Score: 0.730 · neurodegeneration · 2026-04-02
## Mechanistic Overview Adenosine-Astrocyte Metabolic Reset starts from the claim that modulating ADORA2A within the dis
Score: 0.725 · neurodegeneration · 2026-04-02
## Mechanistic Overview TFAM overexpression creates mitochondrial donor-recipient gradients for directed organelle traff
Score: 0.725 · lipidomics · 2026-04-25
ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2 to Protect Synaptic Membranes from Aβ-Induced Rigidificatio
Score: 0.725 · molecular biology · 2026-04-21
**Molecular Mechanism and Rationale** The p16^INK4a-CCF axis represents a sophisticated temporal biomarker system that
Score: 0.720 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome represen
Score: 0.711 · neurodegeneration · 2026-04-02
## Mechanistic Overview Noradrenergic-Tau Propagation Blockade starts from the claim that modulating ADRA2A within the d
Score: 0.710 · neuroscience · 2026-04-22
**Molecular Mechanism and Rationale** The molecular basis for selective liver X receptor beta (LXRβ/NR1H2) agonism in A
Score: 0.710 · neurodegeneration · 2026-04-22
## Mechanistic Overview H4: Senomorphic Compounds Preserve Astrocyte Function While Reversing Senescence starts from the
Score: 0.709 · neurodegeneration · 2026-04-02
## **Molecular Mechanism and Rationale** The lysyl oxidase (LOX) family comprises six enzymes—LOX, LOXL1, LOXL2, LOXL3,
Score: 0.705 · neurodegeneration · 2026-04-21
**Molecular Mechanism and Rationale** The spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and
Score: 0.700 · neurodegeneration · 2026-04-02
## Mechanistic Overview Targeted Butyrate Supplementation for Microglial Phenotype Modulation starts from the claim that