gene 1,521 words KG: NOVA1
Contents

NOVA1 — NOVA Alternative Splicing Regulator 1

🧬 Gene Info
Gene SymbolNOVA1
Full NameNOVA Alternative Splicing Regulator 1
Chromosome14q12
Functionencodes a neuron-specific RNA-binding protein on chromosome 14q12 that is a master regulator of alternative splicing in the nervous system.
Primary ExpressionNeurons (hindbrain, ventral spinal cord, hippocampus, cortex)
Amino Acids512 aa
Exons8
UniProt IDP51513
NCBI Gene ID4857
Ensembl IDENSG00000139910
OMIM602157
GeneCardsNOVA1
Human Protein AtlasNOVA1
Nuclear localization signalDirects NOVA1 to the nucleus for co-transcriptional splicing regulation
Dimerization domainNOVA1 can form homodimers and heterodimers with NOVA2
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Paraneoplastic Opsoclonus-Myoclonus Ataxia (POMA)
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47
Smartphone-Detected Motor Variability Correction
Score: 0.74
Axonal RNA Transport Reconstitution
Score: 0.70
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54

Related Analyses (6)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
mitochondrial-dysfunction-neurodegeneration-comparison
disease · Pages share 4 hypotheses
Familial vs Sporadic Neurodegeneration Comparison
disease · Pages share 4 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 4 hypotheses
TARDBP Mutations in Amyotrophic Lateral Sclerosis
disease · Pages share 4 hypotheses

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