| Gene Symbol | NFE2L1 |
| Full Name | Nuclear Factor Erythroid 2-Like 1 |
| Chromosome | 7q11.23 |
| Protein Type | Transcription Factor |
| Function | NFE2L1 encodes Nrf1 (Nuclear factor erythroid 2-related factor 1), a transcription factor that regulates antioxidant response and proteasome expression. |
| Primary Expression | both neurons and glial cells, where it plays essential roles in maintaining redox balance, regulating proteasome function, and coordinating cellular s |
| Molecular Weight | 90 kDa |
| Amino Acids | 742 aa |
| Pathways | Proteasome Subunit Genes |
| UniProt ID | [Q14145](https://www.uniprot.org/uniprot/Q14145) |
| Ensembl ID | ENSG00000118307 |
| OMIM | 130120 |
| GeneCards | NFE2L1 |
| Human Protein Atlas | NFE2L1 |
| DNA Binding | Forms heterodimers with small Maf proteins (MAFF, MAFG, MAFK) and binds to Antioxidant Response Elements (ARE) with the consensus sequence 5'-TGACnnnGC-3' |
| Associated Diseases | Aging, Als, Alzheimer, Neurodegeneration |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, App, GENES |
| KG Connections | 66 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!