gene

MTCL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTCL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

29Outgoing

6Incoming

0Experiments

0Debates

Summary

MTCL1 encodes a microtubule-associated protein involved in microtubule bundling, neuronal polarity, and axonal transport

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🧬 Gene Info

Gene Symbol	MTCL1
Full Name	Microtubule Cross-Linking Factor 1
Chromosome	21q22.3
Protein Type	Gene
Function	is a human gene encoding a microtubule-associated protein (MAP) that promotes microtubule bundling and stabilization in cells[@shorabe2005].
Primary Expression	the brain, where it plays critical roles in neuronal polarity, axonal transport, and dendritic spine morphogenesis
Molecular Weight	230 kDa
Amino Acids	104 aa
Exons	35
Pathways	COMPLEMENT, Complement, Epigenetic, Wnt
GeneCards	MTCL1
Human Protein Atlas	MTCL1
Coiled-coil motifs	Enable protein dimerization and bundling
EB-binding sites	Interact with end-binding proteins
Phosphorylation sites	Multiple serine/threonine sites for regulation
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AND, App, BETA-CATENIN, C1Q, C1QBP, COMPLEMENT
KG Connections	35 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MTCL1 — Microtubule Cross-Linking Factor 1

gene · 1223 words

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Pathway Diagram

graph TD
    MTCL1["MTCL1"]
    circMTCL1["circMTCL1"]
    MTCL1 -->|"encodes"| circMTCL1
    Carcinoma{"Carcinoma"}
    MTCL1 -->|"activates"| Carcinoma
    Ms{"Ms"}
    MTCL1 -->|"activates"| Ms
    Tumor{"Tumor"}
    MTCL1 -->|"therapeutic target"| Tumor
    MTCL1 -->|"regulates"| Tumor
    C1Q["C1Q"]
    MTCL1 -->|"activates"| C1Q
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    MTCL1 -->|"inhibits"| Ubiquitin_Proteasome
    Epigenetic(["Epigenetic"])
    MTCL1 -->|"activates"| Epigenetic
    Proteasome(["Proteasome"])
    MTCL1 -->|"inhibits"| Proteasome
    Complement(["Complement"])
    MTCL1 -->|"activates"| Complement
    Wnt(["Wnt"])
    MTCL1 -->|"activates"| Wnt
    UBIQUITIN["UBIQUITIN"]
    MTCL1 -->|"activates"| UBIQUITIN
    C1Q -->|"activates"| MTCL1
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"activates"| MTCL1
    AND["AND"]
    AND -->|"activates"| MTCL1
    UBIQUITIN -->|"activates"| MTCL1
    style MTCL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
C1QBP	inhibits	protein	0.80
circMTCL1	encodes	protein	0.72
Ms	activates	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	regulates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Epigenetic	degrades	pathway	0.60
Raf	activates	protein	0.60
App	activates	protein	0.60
C1Q	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
Wnt	activates	pathway	0.60
Invasion	associated_with	pathway	0.60
WNT	activates	gene	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
Ubiquitin-Proteasome	degrades	pathway	0.60
UBIQUITIN	degrades	gene	0.60
Rb	inhibits	protein	0.60
Ubiquitin-Proteasome	inhibits	pathway	0.60
Epigenetic	activates	pathway	0.60
Proteasome	inhibits	pathway	0.60
Complement	activates	pathway	0.60
UBIQUITIN	regulates	protein	0.50
CARCINOMA	activates	disease	0.50
BETA-CATENIN	activates	protein	0.50
UBIQUITIN	inhibits	protein	0.50
CELL PROLIFERATION	associated_with	concept	0.50
COMPLEMENT	activates	pathway	0.50

Incoming (6)

Source	Relation	Type	Str
UBIQUITIN	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
AND	activates	gene	0.60
WNT	activates	gene	0.60
C1Q	activates	gene	0.60
RNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MTCL1 in their description or question text

No additional research found